Liver failure induced by paracetamol.

Acute Liver Failure Caused by Paracetamol Toxicity: a Case Report

Acute liver failure (ALF) is the clinical manifestation of sudden and severe hepatic injury. It is a rare disorder, with an incidence between one and six cases per million people every year in the developed world, and it has a high mortality rate. There are many definitions of ALF, but it is mainly characterised by the presence of encephalopathy during the course of fulminant hepatitis in a pat...

Hyperglycaemia induced by paracetamol.

Sir, Hypoglycaemia is a well-recognised feature of paracetamol overdose, after the development of fulminant hepatic failure, but we are aware of only one previous description of hyperglycaemia and that was in a patient with a family history of diabetes mellitus.' Over recent months we have seen five patients, all male, aged 17 to 40, who have had random blood sugars of 7.2-12.8 mmol/l (mean 9.1...

Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure.

AIM To investigate glucose homeostasis and in particular gluconeogenesis in a large animal model of acute liver failure (ALF). METHODS Six pigs with paracetamol induced ALF under general anaesthesia were studied over 25 h. Plasma samples were withdrawn every five hours from a central vein. Three animals were used as controls and were maintained under anaesthesia only. Using (1)H NMR spectrosc...

Arterial blood lactate measurements quickly identified risk for death from paracetamol-induced liver failure.

Paracetamol as a Possible Cause of Fulminant Liver Failure

Two cases (a 40-year-old man and a 6-year-old child) are presented, in which deaths occurred with symptoms of fulminant liver failure. Mechanical cholaemia was excluded; however, steatosis (in both cases) and an inflammatory state (in the man) of the liver were ascertained. Although no hepatotoxical factor other than paracetamol was ascertained, it could not be unequivocally established as the ...